Patch 26.9 Data
Champion Matchups
Pick two champions and see who wins. Win rates, counters, and tips powered by live ranked data.
Champion 1
Vayne
VS
Champion 2
Karthus
vs
45.7%
Vayne win rate vs Karthus
Karthus has the edge
543
Games Analyzed
45.7%
Vayne WR
54.3%
Karthus WR
-346
Avg Gold Diff @15
Vayne
DamageAD
StyleSustained
RangeRanged
Difficulty****-
StrongLate game
RunesLethal Tempo / Resolve
SummsFlash + Heal
Karthus
DamageAP
StyleSustained
RangeRanged
Difficulty**---
StrongLate game
RunesDark Harvest / Inspiration
SummsFlash + Smite
Power Spike Timeline
Vayne
Level 6
Karthus
Level 6
Vayne
BORK
Karthus
1 item
Vayne
3 items
Karthus
3 items
How to Play This Matchup
Power Curve
Vayne is strongest late game while Karthus peaks late game. Play around your power window.
Mixed Resistances
Vayne deals AD damage while Karthus deals AP. Build resistances accordingly  don't stack the wrong type.
Mirror Playstyle
Both champions play a sustained style. The one with better execution and itemization wins. Focus on spacing and cooldown tracking.
Exploit Vayne's Weakness
Vayne's main weakness: Early lane, burst, hard CC, short range. Play around this to maximize your advantage.
Vayne Win Condition
Scale, shred tanks with W true damage, kite with R+Q
Karthus Win Condition
R global damage, passive keeps dealing damage after death
Recommended Items
Vayne
Blade of the Ruined King
Core
Build every game
Guinsoo's Rageblade
Core
Build every game
Wit's End
Core
Build every game
Mercury's Treads
Defensive
MR + tenacity vs Karthus's AP damage and CC
Hexdrinker
Counter
Magic damage shield vs Karthus's burst
Karthus
Liandry's Anguish
Core
Build every game
Shadowflame
Core
Build every game
Rabadon's
Core
Build every game
Plated Steelcaps
Defensive
Armor boots vs Vayne's AD damage
Bramble Vest
Counter
Grievous wounds + armor vs Vayne's sustain/autos
Vayne's Worst Matchups
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